Workplace activities where contact with 1,4-butanediol may occur is during substance handling (e.g. loading and unloading) at manufacturing facilities. A combination of engineering controls, appropriate respiratory protection and permeation resistant gloves should be used to minimize exposure during product handling and use. Workers should follow the recommended safety measures contained within the (Material) Safety Data Sheet (M/SDS) and on any product packaging. Employees should be trained in the appropriate work processes and safety equipment to limit exposure to chemical substances. Personal Protective Equipment (PPE) should include safety glasses with side shields. Heat protective gloves should also be worn during all hot work activities.