Application | ||
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It is used in medicine, synthesis of compounds, textile chemicals, adhesives, binders, petroleum refining chemicals, fuels, lubricants, coating resins, varnishes, lacquers, agricultural chemicals, cosmetics, ion exchange resins, and photographic chemicals, and as a surfactant |
Description | ||
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Aziridine is an organic compound consisting of the three-membered heterocycle (CH2)2NH. It is a colorless, toxic, volatile liquid that is of significant practical interest. Aziridine was discovered in 1888 by the chemist Siegmund Gabriel. Its derivatives, also referred to as aziridines, are of broader interest in medicinal chemistry. Aziridine is produced industrially from aminoethanol via two related routes. The Nippon Shokubai process requires an oxide catalyst and high temperatures to effect the dehydration. In the Wenker synthesis, the aminoethanol is converted to the sulfate ester, which undergoes base-induced sulfate elimination. Older methods entailed amination of 1,2-dichloroethane and cyclization of 2-chloroethylamine. Aziridine forms a wide variety of polymeric derivatives, known as polyethylenimines. These and related species are useful crosslinking agents and precursors for coatings. Aziridine is highly toxic with an LD50 of 14 mg (oral, rats). It is a skin irritant. As an alkylating agent, it is also a mutagen. It is reactive toward DNA, potentially relevant to its mutagenicity. Aziridine containing compounds also appear to be similarly dangerous. |
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Published | ||
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Oct 29, 2021 |
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Oct 29, 2021 |
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Chemicals |