TCPP is harmful if swallowed, and is irritating to the respiratory system. If ingested, the targeted organs are the liver and bladder.

TCPP can be manufactured by either a batch or continuous process. TCPP is the reaction of phosphorous oxytrichloride with propylene oxide in the presence of a catalyst. The reaction is carried out in a closed reactor. The crude product is washed and dehydrated in a closed vessel to remove acidic impurities and residual catalyst. All transfers are done using closed lines. The product is then filtered, transferred, and packaged using sealed pumps through closed lines. Storage is in closed vessels under nitrogen to exclude moisture and oxygen. TCPP is used as a flame retardant in rigid and flexible polyurethane foam. Its known use is industrial.